tpr file format

Main Table of Contents VERSION 4.0
GROMACS homepage Sun 18 Jan 2009

Description

The tpr file extension stands for portable binary run input file. This file contains the starting structure of your simulation, the molecular topology and all the simulation parameters. Because this file is in binary format it cannot be read with a normal editor. To read a portable binary run input file type:
% gmxdump -s topol.tpr 
or if you're not such a fast reader:
% gmxdump -s topol.tpr | more

You can also compare two tpr files using:

gmxcheck -s1 top1 -s2 top2 | more

http://www.gromacs.org